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differing types of mutations (represented by differently colored arrows) happen at different frequencies (represented by arrow thickness). variety acts being a sieve and enables only a subset of such
https://victorgjub412462.ssnblog.com/29237142/an-unbiased-view-of-44-of-the-world-s-population-has-at-least-the-first-of-5-gene-mutations-and-every-gene-mutation-works-against-you